Free NCLEX-PN Safe and Effective Care Environment – Safety and Infection Control Practice Test – Part 3 (Updated 2026)

1. A client is admitted with confirmed Clostridioides difficile infection. Which hand hygiene method should the LPN/LVN use when caring for this client?

2. The LPN/LVN is preparing to clean the room of a client who was on contact precautions for C. difficile. Which cleaning agent should be requested from environmental services?

3. A client has a wound culture positive for methicillin-resistant Staphylococcus aureus (MRSA). Which action by the LPN/LVN demonstrates appropriate infection control?

4. A client is being discharged after treatment for a MRSA wound infection. The provider orders decolonization therapy. Which instruction should the LPN/LVN include in discharge teaching?

5. A client is admitted with suspected active pulmonary tuberculosis. Which type of room should the LPN/LVN ensure the client is placed in?

6. The LPN/LVN reads a Mantoux tuberculin skin test (PPD) placed 48 hours ago on a healthcare worker. The induration measures 8 mm. Which action is appropriate?

7. A client with active tuberculosis is prescribed a four-drug regimen including isoniazid, rifampin, pyrazinamide, and ethambutol. The LPN/LVN understands that directly observed therapy (DOT) is recommended primarily to:

8. A client with active pulmonary tuberculosis has been on treatment for 3 weeks. Which finding indicates the LPN/LVN can anticipate discontinuing airborne precautions?

9. A client with confirmed COVID-19 requires intubation. Which PPE should the LPN/LVN wear when assisting with this aerosol-generating procedure (AGP)?

10. Which statement by the LPN/LVN indicates correct understanding of infection control for multi-drug resistant organisms (MDROs)?

11. A nurse is preparing to dispose of a used syringe and needle after administering an insulin injection. Which action by the nurse demonstrates proper sharps safety?

12. A nurse notices that the sharps container in a patient’s room is approximately 75% full. What is the most appropriate action?

13. A nurse accidentally sustains a needlestick injury while disposing of a used needle from a patient known to be hepatitis B surface antigen (HBsAg) positive. The nurse’s vaccination status is unknown. What is the priority action?

14. Which color container should be used for disposal of items contaminated with blood or body fluids that are NOT sharps?

15. A nurse is caring for a patient on contact precautions with a multidrug-resistant organism. The patient’s linens are visibly soiled with wound drainage. How should the nurse handle the contaminated linens?

16. A nurse is preparing to assist with a procedure that will generate a significant amount of blood splash. Which personal protective equipment (PPE) combination provides the most appropriate protection?

17. A nurse is using a safety-engineered needle device for a venipuncture. When should the safety mechanism be activated?

18. A nurse discovers a broken glass ampule on the medication room floor. What is the correct procedure for cleanup?

19. Which practice aligns with safe injection practices according to CDC guidelines?

20. A nurse is preparing to dispose of a scalpels used during a minor procedure. The scalpel has a detachable blade. What is the safest approach?

21. A nurse is preparing to perform hand hygiene before assisting a patient with ambulation. According to CDC guidelines, which action demonstrates correct hand hygiene technique?

22. A patient is placed on contact precautions for a methicillin-resistant Staphylococcus aureus (MRSA) wound infection. Which personal protective equipment (PPE) should the LPN/LVN wear when entering the patient’s room?

23. A nurse is caring for a patient with Clostridium difficile (C. diff) infection who has frequent watery diarrhea. The nurse observes a new assistive personnel (AP) entering the room and using alcohol-based hand sanitizer before leaving. What should the nurse do?

24. A patient with active tuberculosis (TB) is being transported from their room to the radiology department for a chest x-ray. Which action by the LPN/LVN is most appropriate during transport?

25. A nurse is preparing to administer medication to a patient. The nurse notices that the medication cart drawer handle appears contaminated with blood. What is the priority action?

26. A patient who had a hip replacement 2 days ago is being assisted out of bed for the first time. The patient is weak and unsteady. Which action by the LPN/LVN best promotes patient safety during ambulation?

27. A nurse is caring for a patient receiving chemotherapy who has developed neutropenia. The patient’s absolute neutrophil count (ANC) is 400 cells/mm³. Which precaution should the LPN/LVN implement?

28. A nurse discovers a small fire in a patient’s bedside trash can. The nurse has already activated the fire alarm and removed the patient from the room. Following the RACE protocol, what should the nurse do next?

29. A patient with a history of falls is admitted to the medical-surgical unit. The patient is confused, takes multiple medications including sedatives, and requires assistance to ambulate. Which combination of interventions provides the MOST comprehensive fall prevention strategy?

30. A nurse is preparing to dispose of contaminated sharps after completing a procedure. The sharps container is located 8 feet away from the procedure area and is three-quarters full. Which action demonstrates safe sharps handling?